Beilstein J. Org. Chem.2014,10, 1488–1494, doi:10.3762/bjoc.10.153
the A-bandpolysaccharide of Pseudomonas aeruginosa. One of the key steps involved 6-O-deoxygenation of either partially or fully acylated 4,6-O-benzylidene-1-thiomannopyranoside by radical-mediated redox rearrangement in high yields and regioselectivity. The D-rhamno-thioglycosides so obtained
-rhamno-trisaccharide. The application of the reported regioselective radical-mediated deoxygenation on 4,6-O-benzylidene D-manno thioglycoside (hitherto unexplored) has potential for ramification in the field of synthesis of oligosaccharides based on 6-deoxy hexoses.
Keywords: A-bandpolysaccharide; D
rendering O-antigen-based vaccines ineffective. But the conservation of the A-bandpolysaccharide even in the colonized form makes this repeating unit a viable candidate for A-bandpolysaccharide-based vaccines which can avoid the vulnerability applicable to their O-antigen-based counterparts [16]. Hence
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Graphical Abstract
Figure 1:
Repeating unit of the A-band polysaccharide of P. aeruginosa.